Text Version
Entrez PubMed
Overview
Help | FAQ
Tutorial
New/Noteworthy
E-Utilities
PubMed Services
Journals Database
MeSH Database
Single Citation Matcher
Batch Citation Matcher
Clinical Queries
LinkOut
Cubby
Related Resources
Order Documents
NLM
Gateway
TOXNET
Consumer
Health
Clinical Alerts
ClinicalTrials.gov
PubMed
Central
Privacy Policy
|
 |
-
The use of spontaneously
hypertensive rats for the study of anti-hypertensive
agents.
Roba JL.
Hypertension studies
using laboratory animals have been conducted since 1930. These were not
completely satisfactory because either surgery or pharmacologic
induction were required to produce hypertensive animals. Many attempts
have been made to breed spontaneously hypertensive rats, mainly from the
Okamoto strain. The cause of hypertension in the rat, with specific
reference to genetic aspects and pathogenicity, were reviewed. The
hypertensive rat is an acceptable model for hypertension studies because
of the stability of the hypertensive state and the reproducibility of
experimental effects. It is a particularly useful model for screening
antihypertensive agents. Development of mutant Okamato stran rats which
have brain softening, cerebral hemorrhages, and myocardial infarctions
would permit the screening of specific therapeutic agents with fewer
side-effects. Mutants which develop obesity, hyperlipidism, and early
atherosclerosis have been reported in Okamoto strain X Sprague-Dawley
rat crosses.
PMID: 131878 [PubMed - indexed for MEDLINE]
|